Targeting the Endocytic Pathway and Autophagy Process as a Novel Therapeutic Strategy in COVID-19
Identifieur interne : 000184 ( Main/Exploration ); précédent : 000183; suivant : 000185Targeting the Endocytic Pathway and Autophagy Process as a Novel Therapeutic Strategy in COVID-19
Auteurs : Naidi Yang [République populaire de Chine] ; Han-Ming Shen [République populaire de Chine]Source :
- International Journal of Biological Sciences [ 1449-2288 ] ; 2020.
Descripteurs français
- KwdFr :
- Animaux, Autophagie, Coronavirus, Endocytose, Humains, Infections à coronavirus (traitement médicamenteux), Infections à coronavirus (virologie), Lignée cellulaire, Pandémies, Pneumopathie virale (traitement médicamenteux), Pneumopathie virale (virologie), Pénétration virale, Thérapie moléculaire ciblée, Virus du SRAS.
- MESH :
- traitement médicamenteux : Infections à coronavirus, Pneumopathie virale.
- virologie : Infections à coronavirus, Pneumopathie virale.
- Animaux, Autophagie, Coronavirus, Endocytose, Humains, Lignée cellulaire, Pandémies, Pénétration virale, Thérapie moléculaire ciblée, Virus du SRAS.
English descriptors
- KwdEn :
- Animals, Autophagy, Betacoronavirus (physiology), Cell Line, Coronavirus, Coronavirus Infections (drug therapy), Coronavirus Infections (virology), Endocytosis, Humans, Molecular Targeted Therapy, Pandemics, Pneumonia, Viral (drug therapy), Pneumonia, Viral (virology), SARS Virus, Virus Internalization.
- MESH :
- drug therapy : Coronavirus Infections, Pneumonia, Viral.
- physiology : Betacoronavirus.
- virology : Coronavirus Infections, Pneumonia, Viral.
- Animals, Autophagy, Cell Line, Coronavirus, Endocytosis, Humans, Molecular Targeted Therapy, Pandemics, SARS Virus, Virus Internalization.
Abstract
Coronaviruses (CoVs) are a group of enveloped, single-stranded positive genomic RNA viruses and some of them are known to cause severe respiratory diseases in human, including Severe Acute Respiratory Syndrome (SARS), Middle East Respiratory Syndrome (MERS) and the ongoing coronavirus disease-19 (COVID-19). One key element in viral infection is the process of viral entry into the host cells. In the last two decades, there is increasing understanding on the importance of the endocytic pathway and the autophagy process in viral entry and replication. As a result, the endocytic pathway including endosome and lysosome has become important targets for development of therapeutic strategies in combating diseases caused by CoVs. In this mini-review, we will focus on the importance of the endocytic pathway as well as the autophagy process in viral infection of several pathogenic CoVs inclusive of SARS-CoV, MERS-CoV and the new CoV named as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and discuss the development of therapeutic agents by targeting these processes. Such knowledge will provide important clues for control of the ongoing epidemic of SARS-CoV-2 infection and treatment of COVID-19.
Url:
DOI: 10.7150/ijbs.45498
PubMed: 32226290
PubMed Central: 7098027
Affiliations:
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Le document en format XML
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Ming" sort="Shen, Han Ming" uniqKey="Shen H" first="Han-Ming" last="Shen">Han-Ming Shen</name><affiliation wicri:level="1"><nlm:aff id="A2">Faculty of Health Sciences, University of Macau, Macau SAR, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Faculty of Health Sciences, University of Macau, Macau SAR</wicri:regionArea><wicri:noRegion>Macau SAR</wicri:noRegion></affiliation></author></analytic><series><title level="j">International Journal of Biological Sciences</title><idno type="eISSN">1449-2288</idno><imprint><date when="2020">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Autophagy</term><term>Betacoronavirus (physiology)</term><term>Cell Line</term><term>Coronavirus</term><term>Coronavirus Infections (drug therapy)</term><term>Coronavirus Infections (virology)</term><term>Endocytosis</term><term>Humans</term><term>Molecular 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SRAS</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Coronaviruses (CoVs) are a group of enveloped, single-stranded positive genomic RNA viruses and some of them are known to cause severe respiratory diseases in human, including Severe Acute Respiratory Syndrome (SARS), Middle East Respiratory Syndrome (MERS) and the ongoing coronavirus disease-19 (COVID-19). One key element in viral infection is the process of viral entry into the host cells. In the last two decades, there is increasing understanding on the importance of the endocytic pathway and the autophagy process in viral entry and replication. As a result, the endocytic pathway including endosome and lysosome has become important targets for development of therapeutic strategies in combating diseases caused by CoVs. In this mini-review, we will focus on the importance of the endocytic pathway as well as the autophagy process in viral infection of several pathogenic CoVs inclusive of SARS-CoV, MERS-CoV and the new CoV named as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and discuss the development of therapeutic agents by targeting these processes. Such knowledge will provide important clues for control of the ongoing epidemic of SARS-CoV-2 infection and treatment of COVID-19.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Weiss, Sr" uniqKey="Weiss S">SR Weiss</name></author><author><name sortKey="Navas Martin, S" uniqKey="Navas Martin S">S Navas-Martin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schoeman, D" uniqKey="Schoeman D">D Schoeman</name></author><author><name sortKey="Fielding, Bc" uniqKey="Fielding B">BC Fielding</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zheng, Y" uniqKey="Zheng Y">Y Zheng</name></author><author><name sortKey="Shang, J" uniqKey="Shang J">J Shang</name></author><author><name sortKey="Yang, Y" uniqKey="Yang Y">Y Yang</name></author><author><name sortKey="Liu, C" uniqKey="Liu C">C Liu</name></author><author><name sortKey="Wan, Y" uniqKey="Wan Y">Y 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Chine</li></country></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Yang, Naidi" sort="Yang, Naidi" uniqKey="Yang N" first="Naidi" last="Yang">Naidi Yang</name></noRegion><name sortKey="Shen, Han Ming" sort="Shen, Han Ming" uniqKey="Shen H" first="Han-Ming" last="Shen">Han-Ming Shen</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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